Effervescent Tablets of Ascorbic Acid. I. Physical Study of the Possible components to Be Used

Autor:	J. Amela, J. Cemeli, R. Salazar
Rok vydání:	1996
Předmět:	Pharmacology Chromatography Moisture Chemistry Organic Chemistry Drug Discovery medicine Pharmaceutical Science Excipient Ascorbic acid medicine.drug
Zdroj:	Drug Development and Industrial Pharmacy. 22:407-416
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049609069349
Popis:	The stability of ascorbic acid effervescent tablets is substantially affected by moisture. Therefore the choice of suitable excipients is a very important step in the formulation study of this type of tablets. This work reviews the most common excipients used in effervescent preparations. They are characterized by microscopical observation and determination of particle size distribution, density, moisture, hygroscopicity, and electrostatics. Hygroscopicity is the most important property when choosing an excipient for an effervescent preparation. Therefore, two different methods for its determination have been used.
Databáze:	OpenAIRE
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