Synthesis and characterization of polysulfanilamide and its copolymers: bioactivity and drug release

Autor:	Seham Mustafa, Abdel-Zaher A. Elassar, Fakhreia Al Sagheer, Abdulhakeem Alsughayer
Rok vydání:	2012
Předmět:	Pharmacology chemistry.chemical_classification Polymer Carbon-13 NMR Acryloyl chloride Thermogravimetry chemistry.chemical_compound chemistry Acrylamide Drug Discovery Polymer chemistry Copolymer Proton NMR Acrylonitrile
Zdroj:	Pharmaceutical Chemistry Journal. 46:418-428
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-012-0813-1
Popis:	Sulfanilamide reacted with acryloyl chloride to give 4-(N-acrylamido)benzenesulfonamide (ABA), which converted to the corresponding polymer (PABA) upon treatment with initiator at 75°C. Various copolymers formed from ABA with acrylamide (AA), acrylonitrile (AN), and N-(thiazol-2-yl)acrylamide (TA) at different ratios (50 : 50, 70 : 30 and 30 : 70) were prepared. The polymer and copolymers were characterized using IR, 1H NMR, 13C NMR and mass spectroscopy, thermogravimetry, and scanning electron microscopy. The drug release from polymeric chain and copolymers was studied at 37°C and pH 8.4. The drug release was highly increased upon adding sodium chloride at various concentrations, 0.1%, 0.5% and 0.9%. The drug release from the polymer and copolymer chains was measured using a UV-visible spectroscopy technique. Antimicrobial activity of the polymer and copolymers was studied. It is established that the ABA copolymer with TA is more effective as compared to other copolymers.
Databáze:	OpenAIRE
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