New Treatment of Medullary and Papillary Human Thyroid Cancer: Biological Effects of Hyaluronic Acid Hydrogel Loaded With Quercetin Alone or in Combination to an Inhibitor of Aurora Kinase
| Autor: | Emilia Armenia, Caterina Aurilio, Francesco Rosso, Alfonso Barbarisi, Vincenzo Quagliariello, Manlio Barbarisi, Gabriele De Sena, Ottavia Clemente |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
biology Physiology Chemistry Clinical Biochemistry CD44 Cell Cell Biology medicine.disease Papillary thyroid cancer 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Aurora kinase 030220 oncology & carcinogenesis Hyaluronic acid Self-healing hydrogels Cancer research biology.protein medicine heterocyclic compounds Viability assay Thyroid cancer |
| Zdroj: | Journal of Cellular Physiology. 231:1784-1795 |
| ISSN: | 0021-9541 |
| DOI: | 10.1002/jcp.25283 |
| Popis: | The aim of this paper is based on the use of a hyaluronic acid hydrogel of Quercetin tested alone and in combination to an inhibitor of Aurora Kinase type A and B (SNS-314) on human medullary and papillary thyroid cancer cells. Biological investigations were focused on the cellular uptake of the hydrogel, cell viability, antioxidant, and cytokines secretion studies. Quercetin delivered from hydrogel show a time and CD44 dependent interaction with both cell lines with significant anti-inflammatory effects. Combination of Quercetin and SNS-314 leads to a synergistic cytotoxic effect on medullary TT and papillary BCPAP cell lines with a significant reduction of the IC50 value. These results, highlights the importance of synergistic effect of the hyaluronic acid hydrogel of Quercetin with SNS-314 in the regulation of human thyroid cancer cell proliferation and emphasize the anti-tumor activity of these molecules. J. Cell. Physiol. 231: 1784-1795, 2016. © 2015 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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