Nitric oxide and differential regional mucosal blood flow distribution of the intestine in lipopolysaccharide induced shock in the rat
| Autor: | J.C. Barreto, F.G. Moody, K. Klemm |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Hepatology Lipopolysaccharide Chemistry Septic shock Gastroenterology Ileum medicine.disease Nitric oxide Jejunum chemistry.chemical_compound Basal (phylogenetics) medicine.anatomical_structure Endocrinology Shock (circulatory) Internal medicine medicine Duodenum medicine.symptom |
| Zdroj: | Gastroenterology. 108:A296 |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/0016-5085(95)23842-5 |
| Popis: | NITRIC OXIDE AND DIFFERENTIAL REGIONAL MUCOSAL BLOOD FLOW DISTRIBUTION OF THE ' INTESTINE IN LIPOPOLYSACCHARIDE INDUCED SHOCK IN THE RAT. K Klemm I C Barreto and F G Moody Dept. of Surgary, University of Texas Medical School, Houston, TX Introduction: Nitric oxide (NO) is an important regulator of mucosal blood flow (BF) in the intestine. Lipepolysacchatide (LPS)-induced NO upregulatian increases from duodenum to ileum (Gastroet~eroiogy 106 [Suppl.]: A510, 1994). We investigated regional mucosal BF in intestine, BF alteration in septic shock and the effect of Ne)-nitre-L-argininemethylester (L-NAME), a NO-synihase inhibitor, ca regional mucosal BF. Methods: BF was measured in conscious, unrestrained rats with microsphere$ before anytreatmem (basal), and 2h, 411 and 611 after treatmetR. Treatments: LPS 20 mg/kg bw i.p. (n=8), LPS + L-NAME 5 mg/kg bw s.c. (n=8) and L-NAME alone (n=g). An untreated group (n=6) showed no difference to a saline-treated group (0.9% saline i.p., n=8); both groups were pooled (n=14). Randomization to treatment groups followed after basal BF measurement and was pooled (n=38). Results: Mucmml blood flow to different intestinal r t l lom Igmps dso~um I ~janum I ileum ] colon I basal 254+12",d 1244±13 d I 395±14 I~,c,a I 142-~ c,d I a:cmtrol2h 238"+'23b'd I 242"+'33a 1411+i4b'c'al143+16c'd I h=LPS 2h 3 ~ 7 3 ,,a I 302*57 ~c 1 22Z~9*,a I 150~i c,d I c-LPS+L-NAME 2h 191-+-29 b 1186d:!7 la I 180~11 ,,a I 874-13 ,,a,D I d:L-NAME 2h 123:1:13 ,,a,b I 165+16 ,,a,b I 208.+.29 *,a I 834"!5 *,a,b [ * significantly different to basal, a'd significantly different to ctm'espond~ng group (2-way ANOVA, p |
| Databáze: | OpenAIRE |
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