Study Into Antinociceptive Activity of a New Molecule from the Class of Hexaazaizowurzitane
| Autor: | E. A. Kiseleva, S. G. Krylova, T. N. Povet`eva, Yu. V. Nesterova, O. G. Afanas`eva, P. V. Kul`pin, D. A. Kulagina, E. P. Zueva, N. I. Suslov, V. V. Eremina, O. V. Baibakova, S. V. Sysolyatin, V. V. Zhdanov |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal Biomed. 19:61-72 |
| ISSN: | 2713-0428 2074-5982 |
| Popis: | In this work, we studied the pharmacological activity of a newly-synthesized compound 4-(3,4- dibromothiophenylcarbonyl)-10-(2-ethoxyacetyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,03,11,05,9]dodecane (M3) using somatogenic pain models of various genesis (thermal and visceral pain, mechanical compression of a paw). The compound showed a high antinociceptive efficacy, comparable to or exceeding that of tramadol. It was shown that the new molecule from the class of hexaazaisowurtzitane effectively blocks nociceptive reactions at the supraspinal and peripheral levels of pain sensitivity organization. The results obtained confirm the possibility of creating new pharmacologically active molecules based on the high-energy substance of hexaazaisowurtzitane, which is a priority in domestic pharmaceutical production. |
| Databáze: | OpenAIRE |
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