A rare case of Holmes tremor in a worker with occupational carbon monoxide poisoning
| Autor: | Jonathan S. Rutchik, Marcia H. Ratner, Rosemarie M. Bowler |
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| Rok vydání: | 2021 |
| Předmět: |
Carbon monoxide poisoning
business.industry Parkinsonism Encephalopathy Public Health Environmental and Occupational Health Excitotoxicity Toxic encephalopathy medicine.disease medicine.disease_cause Indirect pathway of movement 030210 environmental & occupational health Holmes tremor 03 medical and health sciences 0302 clinical medicine Anesthesia Basal ganglia medicine 030212 general & internal medicine business |
| Zdroj: | American Journal of Industrial Medicine. 64:435-449 |
| ISSN: | 1097-0274 0271-3586 |
| DOI: | 10.1002/ajim.23235 |
| Popis: | Parkinsonism and encephalopathy are frequently seen in patients who survive carbon monoxide (CO) poisoning. Neurological findings associated with CO poisoning can emerge immediately after cessation of exposure or following a brief period of pseudo-recovery. When present, the tremor associated with CO poisoning is typical of the postural/intention type. Here, we report on a rare case of toxic encephalopathy with a dominant-hand Holmes-type tremor, characterized by resting, as well as postural and kinetic/intentional components, in a previously healthy 53-year-old man exposed to CO while actively engaged in the process of performing a physically demanding skilled labor task. The unique neuropathological and functional changes that give rise to Holmes-type tremor and how this relates to the selective vulnerability of the inhibitory indirect pathway of the basal ganglia to glutamatergic excitotoxicity mediated by tissue hypoxia are discussed. |
| Databáze: | OpenAIRE |
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