Transfer Learning Approach to Predict Biopsy-Confirmed Malignancy of Lung Nodules from Imaging Data: A Pilot Study
| Autor: | Eduardo J. Mortani Barbosa, William D. Lindsay, Nicholas Sachs, Jiancong Wang, James C. Gee |
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| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Image Analysis for Moving Organ, Breast, and Thoracic Images ISBN: 9783030009458 RAMBO+BIA+TIA@MICCAI |
| DOI: | 10.1007/978-3-030-00946-5_29 |
| Popis: | The goal of this study is to train and assess the performance of a deep 3D convolutional network (3D-CNN) in classifying indeterminate lung nodules as either benign or malignant based solely on diagnostic-grade thoracic CT imaging. While prior studies have relied upon subjective ratings of malignancy by radiologists, our study relies only on data from subjects with biopsy-proven ground truth labels. Our dataset includes 796 patients who underwent CT-guided lung biopsy at one institution between 2012 and 2017. All patients have pathology-confirmed diagnosis (from CT-guided biopsy) and high-resolution CT imaging data acquired immediately prior to biopsy. Lesion location was manually determined using the biopsy guidance CT scan as a reference for a subset of 86 patients for this proof-of-concept study. Rather than training the network without a priori knowledge, which risks over fitting on small datasets, we employed transfer learning, taking the initial layers of our network from an existing neural network trained on a distinct but similar dataset. We then evaluated our network on a held out test set, achieving an area under the receiver operating characteristic curve (AUC) of 0.70 and a classification accuracy of 71%. |
| Databáze: | OpenAIRE |
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