GnRH agonist (GnRHa) priming increases the number of in vitro matured (IVM) oocytes available for cryopreservation in cancer patients seeking urgent fertility preservation (FP)
| Autor: | Nelly Frydman, S. Le Parco, R. Fanchin, Michael Grynberg, M. Poulain, H. El Hachem |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.drug_class Letrozole Obstetrics and Gynecology Oocyte Antral follicle Cryopreservation medicine.anatomical_structure Endocrinology Human fertilization Reproductive Medicine Internal medicine Follicular phase medicine Fertility preservation Gonadotropin business medicine.drug |
| Zdroj: | Fertility and Sterility. 100:S118 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2013.07.1654 |
| Popis: | E2 and follicular size and may complicate clinical decision making. This study seeks to determine whether continuous AI use throughout stimulation impacts oocyte maturity and function. DESIGN: Retrospective. MATERIALS AND METHODS: FP patients with breast cancer treated with an AI (letrozole) were compared to FP patients with other malignancies not using AIs. The AI group had oocyte maturation induced when leading follicles reached 20mm as suggested by Oktay et al, compared with the standard of 18mm. Endocrine levels, oocyte maturity (MII/retrieved oocytes), MII yield (MII/follicles R14mm) and fertilization rates were compared. RESULTS: 24 AI patients were compared with 22 controls. The age, AMH, and antral follicle counts were equivalent. In contrast to prior reports, total gonadotropin usage was similar. The AI group had lower peak E2 levels (536 vs 1972 pg/mL; P 400 pg/mL). The AI group had higher peak P levels (1.1 vs 0.7 ng/mL; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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