Skin-depigmenting prodrugs of hydroquinone

Autor:	Z Ben-Ishai, M Ruse, Abraham Nudelman, J Schamroth
Rok vydání:	1993
Předmět:	Pharmacology integumentary system Hydroquinone Chemistry Stereochemistry Organic Chemistry General Medicine Prodrug Combinatorial chemistry Dosage form chemistry.chemical_compound Depigmentation Drug Discovery medicine medicine.symptom
Zdroj:	European Journal of Medicinal Chemistry. 28:159-164
ISSN:	0223-5234
DOI:	10.1016/0223-5234(93)90008-3
Popis:	Novel mono- 1 and bis-carbonates 2 , and mono- 3 and bis-pivaloyloxymethyl ethers 4 (bis-POM-ethers) of hydroquinone (HQ) evaluated as skin-lightening agents, showed that: 1) they cause an initial depigmentation of the skin; 2) the depigmenting effect is not maintained over prolonged periods of time; and 3) prolonged use results in a shift of the chromatic locus, suggesting the formation of a new chemical product in the skin. HQ was a more potent depigmenting agent than any of the derivatives tested.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::25de629d8d4fc117e10c646b35b75796 https://doi.org/10.1016/0223-5234(93)90008-3 Zobrazit plný text záznamu