Discovering Epimodifications of the Genome, Transcriptome, Proteome, and Metabolome: the Quest for Conquering the Uncharted Epi(c) Territories
| Autor: | Yan-Ming Xu, Andy T. Y. Lau, Fei-Yuan Yu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology Genetics 030102 biochemistry & molecular biology Pharmacology toxicology Epigenome Computational biology Biology Biochemistry Genome Transcriptome 03 medical and health sciences 030104 developmental biology Drug Discovery Proteome otorhinolaryngologic diseases Metabolome DECIPHER |
| Zdroj: | Current Pharmacology Reports. 3:286-293 |
| ISSN: | 2198-641X |
| DOI: | 10.1007/s40495-017-0103-4 |
| Popis: | In this review, we would like to present the overall concepts of “-omes−epi-omes” interactions, i.e., the interactions among the four most noticeable “-omes” (genome, transcriptome, proteome, and metabolome) to the four “epi-omes” (epigenome, epitranscriptome, epiproteome, and epimetabolome) as well as discussing the recently identified epimodifications in humans. With the advancement of mass spectrometry and sequencing technologies, novel epimodifications/epi-marks are gradually revealed in recent years. Nowadays, it is becoming clear that all the constituents of the genome, transcriptome, proteome, and even the metabolome can further be modified/decorated with various epi-marks. Given the fact that a variety of modifications can occur in DNA/RNA, proteins, and metabolites, it is possible that an unknown number of epimodifications/epi-marks might exist and are yet to be discovered. The ability to decipher and manipulate the epi-omes might present new avenues in drug design for procuring better treatment of various human diseases. |
| Databáze: | OpenAIRE |
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