Recurrence and Resistance Patterns of Herpes Simplex Virus following Cessation of >=6 Years of Chronic Suppression with Acyclovir
| Autor: | Gloria S. Boone, Kenneth H. Fife, Gregory J. Mertz, Edgar L. Hill, Clyde S. Crumpacker |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Drug resistance Biology medicine.disease_cause biology.organism_classification Gastroenterology Herpesviridae Virus Surgery Infectious Diseases Herpes simplex virus Internal medicine Alphaherpesvirinae medicine Immunology and Allergy Viral disease Aciclovir Immunocompetence medicine.drug |
| Zdroj: | Journal of Infectious Diseases. 169:1338-1341 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Questions have arisen regarding the clinical outcome and the possible selection of resistant virus when patients with genital herpes discontinue prolonged chronic acyclovir; 239 immunocompetent patients with a history of frequently recurring genital herpes who stopped successful suppressive therapy after 6 years were studied. Of the patients, 85.8% had at least one recurrence and 75% had at least two recurrences in the subsequent year (median time to first and second recurrence, 68 and 180 days, respectively). Herpes simplex virus isolates recovered from these patients had a median acyclovir sensitivity of 0.79 micrograms/mL and 4 (3.5%) were resistant (> or = 3 micrograms/mL). These values are comparable to those of pretherapy isolates and to reported values of isolates from acyclovir-naive patients. Also, paired pre- and posttherapy isolates from 13 patients showed no trend toward development of resistance. Thus, even after 6 years of acyclovir suppression, most patients continue to have recurrences, but the selection of resistant virus has not been observed. |
| Databáze: | OpenAIRE |
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