Enantioselectivity vs. kinetic resolution in antibody catalysis: formation of the (S) product despite preferential binding of the (R) intermediate
| Autor: | Doron Shabat, Ehud Keinan, Hagit Shulman, Harel Itzhaky, Jean-Louis Reymond |
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| Rok vydání: | 1998 |
| Předmět: |
biology
Stereochemistry Metals and Alloys Ether General Chemistry Preferential binding Enol Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Kinetic resolution chemistry.chemical_compound chemistry Materials Chemistry Ceramics and Composites biology.protein Racemic mixture Stereoselectivity Antibody |
| Zdroj: | Chemical Communications. :1759-1760 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/a802374c |
| Popis: | Antibody 14D9, which catalyzes the stereoselective transformation of achiral enol ethers into the corresponding (S)-ketals, resolves a racemic mixture of structurally similar chiral enol ethers by selective conversion of the (R)-enol ether into the (R)-ketal, raising the possibility that the (S) transition state is preferencially stabilized by the antibody despite a better binding of the (R) intermediate. |
| Databáze: | OpenAIRE |
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