Localized submassive liver cell necrosis as a terminal event of liver carcinoma

Autor: Toshiro Nakashima, Y. Kubo, Harushige Kanno, Eisuke Nagata, Kazuyoshi Sakamoto, Hirotaka Musha, Masamichi Kojiro, Tsuneaki Arishima, Masahiko Igarashi, Yutaka Shimokawa, Kunio Okuda, Masayuki Nakano, Masaharu Hashimoto
Rok vydání: 1976
Předmět:
Zdroj: Cancer. 37:1965-1972
ISSN: 1097-0142
0008-543X
Popis: Six cases of hepatocellular carcinoma (HCC) and one case of metastatic liver carcinoma in which SGOT, SGPT, and SLDH were suddenly and markedly elevated immediately before death are described. All had a large blood loss and systemic hypotension in the preterminal period; autopsy disclosed irregularly shaped, patchy necrotic areas or infarcts, often clearly demarcated by hemorrhagic rims, in the noncancerous liver parenchyma. Tumor growths in the intrahepatic portal branches were extensive in all six cases with HCC; in the metastatic case, invasion and narrowing of the portal branches were extensive. The incidence of this terminal catastrophe was 3.3% (6 of 184 cases) for HCC and 1.15% (1 of 87) for metastatic carcinoma. The terminal liver necrosis was probably a result of sudden reduction in portal perfusion which had been inadequate because of tumor thrombosis, combined with hypotension of hepatic arteries.
Databáze: OpenAIRE
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