Fibrinogen Haifa: Fibrinogen Variant with Absence of Protective Effect of Calcium on Plasmin Degradation of Gamma Chains

Autor:	Agnes Henschen, Claudine Soria, M Samama, W. Nieuwenhuizen, S Tabori, M Kehl, A Rimon, Jeannette Soria, I Tatarski
Rok vydání:	1987
Předmět:	biology medicine.diagnostic_test Plasmin Chemistry chemistry.chemical_element Hematology Thrombin time Calcium Cleavage (embryo) Fibrinogen Cofactor Biochemistry biology.protein medicine Factor XIIIa Polyacrylamide gel electrophoresis medicine.drug
Zdroj:	Thrombosis and Haemostasis. 57:310-313
ISSN:	2567-689X 0340-6245
Popis:	SummaryThe abnormal fibrinogen Haifa is characterized by the fact that calcium present during enzymatic digestion by plasmin does not protect the Haifa D gamma chain against further plasmin attack as it does in normal molecules.Since calcium binding to fibrinogen, ADP - platelet aggregation cofactor activity and gamma dimerization process induced by factor XIIIa are normal for fibrinogen Haifa, the corresponding sequences in the gamma chain are not involved. It seems rather that the anomaly resides near the gamma 302 plasmin cleavage site that is protected when calcium is bound to the gamma chain and that this affects the availability of the polymerization site located in the C terminal part of the chain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::25cd9b3e823b73c42d4d9787501d3091 https://doi.org/10.1055/s-0038-1651123 Zobrazit plný text záznamu