Abstract 4935: Development of a human pancreatic tumor microenvironment system (TMeS) for evaluation of novel therapeutics

Autor:	Chelsi J Snow, Brian R. Wamhoff, Todd W. Bauer, Robert A. Figler, Michael B. Simmers, Stephen A. Hoang, J. Thomase Parsons, Daniel Gioeli
Rok vydání:	2017
Předmět:	Oncology Cancer Research medicine.medical_specialty business.industry Pancreatic tumor Internal medicine Medicine business medicine.disease
Zdroj:	Cancer Research. 77:4935-4935
ISSN:	1538-7445 0008-5472
DOI:	10.1158/1538-7445.am2017-4935
Popis:	The development of drugs to treat cancer is severely hampered by the inefficiency of translating pre-clinical in vitro and mouse studies into clinical benefit. Over 90% of drugs that progress through pre-clinical studies fail in human trials. Therefore, there is a critical need to improve the accuracy of evaluating pre-clinical drug efficacy through the development of more physiologically relevant human models. This is especially the case for pancreatic cancer, the 4th leading cause of cancer deaths with a 5-year survival rate of Citation Format: Daniel G. Gioeli, Chelsi Snow, Michael Simmers, Robert Figler, J. Thomase Parsons, Stephen Hoang, Todd Bauer, Brian Wamhoff. Development of a human pancreatic tumor microenvironment system (TMeS) for evaluation of novel therapeutics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4935. doi:10.1158/1538-7445.AM2017-4935
Databáze:	OpenAIRE
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