Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

Autor: Katja Biering Leth-Møller, Raymond Noordam, Harald Grallert, Konstantin Strauch, Holger Schulz, Line Lund Kårhus, Matthias Nauck, Tea Skaaby, Guy Brusselle, Line Tang Møllehave, Yuvaraj Mahendran, Diana Kuh, Janne Schurmann Tolstrup, Arturo Gonzalez-Quintela, Dennis O. Mook-Kanamori, Henry Völzke, Niels Grarup, Betina H. Thuesen, Amy E Taylor, Thomas Meitinger, Tarunveer S. Ahluwalia, Rebecca Hardy, Ang Zhou, David J. Stott, Lavinia Paternoster, Elina Hyppönen, Andrew Wong, Uwe Völker, Annette Peters, Tobias Bonten, Christian Theil Have, Stephen Burgess, Ayesha Sajjad, Marcus R. Munafò, Henning Tiemeier, Stella Trompet, Lies Lahousse, Tuomas O. Kilpeläinen, Christian Taube, C Power, Allan Linneberg, Daniel Mønsted Shabanzadeh, J. Wouter Jukema, Nele Friedrich, Torben Hansen, Claudia Flexeder, Oluf Pedersen
Rok vydání: 2018
Předmět:
Zdroj: Addiction. 114:216-225
ISSN: 0965-2140
Popis: Aims: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E. Design: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions. Setting: Europe. Participants: We included a total of 466 434 people aged 15–82 years from 17 population-based studies conducted from 1997 to 2015. Measurements: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples. Findings: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI = 0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = –5.5%, 14.9%; P = 0.366) for total IgE. Conclusions: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.
Databáze: OpenAIRE
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