Comparative Studies on DNA Binding, Photocleavage, and Photophysical Properties of Ru(II) Complexes Containing TIP {TIP = 2-(Thiophen-2-yl)-1H-imidazo[4,5-f][1,10]-phenanthroline} Ligand
| Autor: | V. Ravi Kumar, Gurram Srinivas, Sirasani Satyanarayana, K. Laxma Reddy, Y. Praveen Kumar |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
030103 biophysics Ligand Phenanthroline Intercalation (chemistry) General Chemistry Carbon-13 NMR 010402 general chemistry 01 natural sciences Binding constant 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound Crystallography chemistry Cleave Thiophene DNA |
| Zdroj: | Russian Journal of General Chemistry. 88:2621-2627 |
| ISSN: | 1608-3350 1070-3632 |
| Popis: | A thiophene contained imidazo phenanthroline ligand TIP {TIP = 2-(thiophen-2-yl)-1H-imidazo-[4,5-f][1,10]phenanthroline{ and its mononuclear Ru(II) polypyridyl complexes [Ru(phen)2TIP]2+ (1) (phen = 1,10-phenanthrolene) and [Ru(bpy)2TIP]2+ (2) (bpy = 2,2'-bipyridyl), are synthesized and characterized by UVVis, IR, 1H and 13C NMR, and ESI-MS spectra. Interaction of these complexes with CT-DNA is studied using UV-Vis and florescence spectra, viscosity measurements and molecular docking studies. The latter supports binding ability of complexes with stability constants deduced from UV-Vis and florescence spectra. The studies reveal that both Ru(II) polypyridyl complexes bind to DNA predominantly by intercalation, and the binding constant of complex 1 is greater than that of complex 2. Complexes 1 and 2 cleave the pBR 322 DNA under UV light. |
| Databáze: | OpenAIRE |
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