Hepatic insulin clearance is the primary determinant of insulin sensitivity in the normal dog
| Autor: | Darko Stefanovski, Vahe Mooradian, Karyn J. Catalano, Jenny D. Chiu, Stella P. Kim, Justin Dittmann, Dan Zheng, Orison O. Woolcott, Morvarid Kabir, Cathryn M. Kolka, Richard N. Bergman, Gregg W. Van Citters, Sophia Yae, Maya Lottati, Marilyn Ader, Viorica Ionut, Lisa N. Harrison, Huiwen Liu, Katrin Hücking, Joyce M. Richey, Isabel R. Hsu, Martin Ellmerer, Ana Valeria B. Castro |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Medicine (miscellaneous) 030209 endocrinology & metabolism Type 2 diabetes 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Internal medicine Diabetes mellitus Hyperinsulinemia Medicine 030304 developmental biology 2. Zero hunger 0303 health sciences Nutrition and Dietetics business.industry Insulin Glucose clamp technique medicine.disease Obesity 3. Good health business Hyperinsulinism |
| Zdroj: | Obesity. 22:1238-1245 |
| ISSN: | 1930-7381 |
| DOI: | 10.1002/oby.20625 |
| Popis: | Objective Insulin resistance is a powerful risk factor for Type 2 diabetes and a constellation of chronic diseases, and is most commonly associated with obesity. We examined if factors other than obesity are more substantial predictors of insulin sensitivity under baseline, nonstimulated conditions. Methods Metabolic assessment was performed in healthy dogs (n = 90). Whole-body sensitivity from euglycemic clamps (SICLAMP) was the primary outcome variable, and was measured independently by IVGTT (n = 36). Adiposity was measured by MRI (n = 90), and glucose-stimulated insulin response was measured from hyperglycemic clamp or IVGTT (n = 86 and 36, respectively). Results SICLAMP was highly variable (5.9-75.9 dl/min per kg per μU/ml). Despite narrow range of body weight (mean, 28.7 ± 0.3 kg), adiposity varied approximately eight-fold and was inversely correlated with SICLAMP (P |
| Databáze: | OpenAIRE |
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