1378-P: Gluten-Free Diet in Children with Recent-Onset Type 1 Diabetes without Coeliac Disease: A 12-Month Intervention Trial
| Autor: | Vit Neuman, Ondrej Cinek, Michal Kulich, Barbora Obermannova, Martina Romanova, Jan Vosahlo, Lenka Petruzelkova, Stanislava Kolouskova, Zdenek Sumnik, Stepanka Pruhova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Type 1 diabetes medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment Area under the curve medicine.disease Gluten Gastroenterology Coeliac disease chemistry Internal medicine Internal Medicine Medicine Gluten free Intervention trial business Recent onset |
| Zdroj: | Diabetes. 68 |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | Objectives: Data on the role of gluten in type 1 diabetes (T1D) are scarce. We aimed to test whether gluten-free diet (GFD) can decelerate the decline in beta-cell capacity in newly diagnosed non-celiac T1D children. Methods: Forty-six children (aged 10.2±3.3 years) were recruited into this non-randomized self-selected intervention trial: 26 started with GFD whereas 20 remained on standard diet. Main outcomes were the decline in C-peptide area under the curve (AUC) in mixed-meal tolerance tests and the differences in insulin dose, insulin dose adjusted A1c (IDAA1c) and HbA1c at 12 months. Data were analyzed as intention-to-treat by linear regression models adjusted for baseline parameters. The adherence to GFD was tested by immunoreactive gluten in stool. Results: Mean decrease in C-peptide AUC was 293 vs.484 pmol/L (p=0.3) at 6 months, and 567 vs. 919 pmol/L (p=0.1) at 12 months in GFD and control group, respectively. The GFD group had a lower insulin dose by 0.22 U/kg/day (p=0.007), lower IDAA1c by 1.5 (p=0.003) and lower mean HbA1c by 7.5 mmol/mol (p=0.01) at 12 months (Figure 1). There was no difference in daily carbohydrate intake between the groups (p=0.4). Immunoreactive gluten was found in the stool of only 3 patients. Conclusions: GFD kept over the first year after T1D diagnosis was associated with lower insulin demand and lower HbA1c, although the groups did not differ in the C-peptide dynamics. Disclosure V. Neuman: None. S. Pruhova: None. M. Kulich: None. S. Koloušková: None. J. Vosahlo: None. M. Romanova: None. L. Petruzelkova: None. B. Obermannova: None. O. Cinek: None. Z. Sumnik: None. Funding Ministry of Health of the Czech Republic (16-27994A) |
| Databáze: | OpenAIRE |
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