Endothelial-derived extracellular vesicles from obese/hypertensive adults increase factors associated with hypertrophy and fibrosis in cardiomyocytes

Autor: Hannah K. Fandl, Vinicius P. Garcia, John W. Treuth, Lillian M. Brewster, Jared J. Greiner, Kevin P. Davy, Brian L. Stauffer, Christopher A. Desouza
Rok vydání: 2023
Předmět:
Zdroj: American Journal of Physiology-Heart and Circulatory Physiology. 324:H675-H685
ISSN: 1522-1539
0363-6135
DOI: 10.1152/ajpheart.00035.2023
Popis: In the present study we determined the effect of endothelial microvesicles (EMVs) isolated from obese/hypertensive adults on mediators of cardiomyocyte hypertrophy [cardiac troponin T (cTnT), α-actinin, nuclear factor-kB (NF-kB)] and fibrosis [transforming growth factor (TGF-β), collagen1-α1] as well as endothelial nitric oxide synthase (eNOS) expression and NO production. EMVs from obese/hypertensive induced significantly higher expression of hypertrophic (cTnT, α-actinin, NF-kB) and fibrotic (TGF-β) proteins as well as significantly lower eNOS activation and NO production in cardiomyocytes than EMVs from normal weight/normotensive adults. EMVs are a potential mediating factor in the increased risk of cardiomyopathy and heart failure with obesity/hypertension.
Databáze: OpenAIRE