Effects of Vitamins C and E on Free Radical Processes in the Blood of Rats in Acute Moderate Hypothermia
| Autor: | M. D. Astaeva, N. K. Klichkhanov, Zh. G. Ismailova, Sh. I. Chalabov |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine Vitamin medicine.medical_specialty medicine.medical_treatment Biology medicine.disease_cause 010603 evolutionary biology 01 natural sciences General Biochemistry Genetics and Molecular Biology Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Internal medicine medicine Vitamin C Vitamin E Glutathione Hypothermia Ascorbic acid 030104 developmental biology Endocrinology chemistry medicine.symptom General Agricultural and Biological Sciences Oxidative stress |
| Zdroj: | Biology Bulletin. 46:536-543 |
| ISSN: | 1608-3059 1062-3590 |
| Popis: | We assessed the effect of intraperitoneal administration of ascorbic acid (vitamin C, 100 mg/kg/day) and α-tocopherol (vitamin E–selenium, 40 mg/kg/day), given alone or in combination for seven days, on the intensity of free-radical processes in the blood of rats in acute short-term hypothermia of 30○С. Hypothermia contributes to the development of oxidative stress in erythrocytes, stimulating the lipid peroxidation and oxidative modification of proteins (OMP), decreasing the content of glutathione (GSH) and increasing the activity of superoxide dismutase (SOD) in erythrocytes. A separate administration of vitamins prevents a decrease in the level of GSH and an increase in the activity of SOD in erythrocytes in hypothermia, but vitamin C stimulates lipid peroxidation and OMP and vitamin E stimulates OMP of the erythrocyte membranes. Coadministration of vitamins C and E completely prevents the development of oxidative stress in erythrocytes during hypothermia. |
| Databáze: | OpenAIRE |
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