| Autor: |
Haider Falih Shamikh Al-Saedi, Haider F. Al-Saedi, Mukhallad Abdul Kareem Ramadhan, Adeeb Ahmed Kadhim Al-Zubaidy, Hussein Abdelamir Mohammad |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
International Journal of Research in Pharmaceutical Sciences. 10:795-802 |
| ISSN: |
0975-7538 |
| DOI: |
10.26452/ijrps.v10i2.255 |
| Popis: |
Imiquimod-induced psoriasis is an animal model of psoriasis. The antidiabetic metformin had anti-inflammatory, immunomodulation, antiangiogenesis and antiproliferative effect. The objective of this study was to evaluate the possible beneficial effect of metformin gel against imiquimod-induced psoriasis-like form by scoring the erythema and scaling besides measuring of tissue homogenate levels of IL17/IL23. Swiss albino mice were used in this experiment imiquimod 5% cream applied on shaved back of mice for six days, and this is an induction group and compared with a negative control group that involved mice treated with ointment base only for six days. Third group; metformin 10% gel applied on the back of mice with imiquimod for six days. The fourth group included used of metformin 15% gel with imiquimod for six days. This data was analysed for significant level when p ≥ 0.05 by using either ANOVA test for biochemical parameters levels evaluation. Furthermore, imiquimod 5% cream of induction group caused an elevation of inflammatory parameters; IL17 and IL23 in skin tissue homogenate when being compared to IL17 and IL23 level of the control group. Whereas, metformin 10% gels showed levels of IL17 and IL23 with significant different from induction group. In addition, metformin 15% gels exerted a significantly low level of IL17 and IL23. The possible considerable antipsoriatic activity of topical metformin gel through reducing scaling and erythema and mediated through modest anti-inflammatory effects by suppressing levels of IL17/23. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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