Antimicrobial evaluation and action mechanism of chalcone derivatives containing quinoxaline moiety
| Autor: | Shijun Su, Xu Tang, Mei Chen, Jun He, Wei Xue, Xia Rongjiao, Jiang Shichun, Guo Tao, Ying Chen |
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| Rok vydání: | 2019 |
| Předmět: |
Ralstonia solanacearum
Chalcone biology 010405 organic chemistry Stereochemistry General Chemistry 010402 general chemistry Antimicrobial biology.organism_classification 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Quinoxaline Xanthomonas oryzae chemistry Moiety Antibacterial activity EC50 |
| Zdroj: | Monatshefte für Chemie - Chemical Monthly. 150:1325-1334 |
| ISSN: | 1434-4475 0026-9247 |
| DOI: | 10.1007/s00706-019-02449-9 |
| Popis: | A series of chalcone derivatives containing quinoxaline moieties were synthesized, and their antibacterial activities were evaluated. Antibacterial bioassays indicated that some of the compounds exhibited significant antibacterial activity against Xanthomonas axonopodis pv. Citri (Xac), Xanthomonas oryzae pv. oryzae (Xoo), and Ralstonia solanacearum (Rs) at the concentrations of 50 or 100 μg/cm3. 50% effective concentration (EC50) values of (E)-3-(pyridin-2-yl)-1-[4-(quinoxalin-2-yloxy)phenyl]prop-2-en-1-one against Xac, Xoo, and Rs were 6.72, 15.17, and 9.29 μg/cm3, respectively, which were better than those of bismerthiazol (44.31, 42.46, and 62.36 μg/cm3, respectively). Scanning electron microscopy (SEM) was employed to analyze the mechanism of antibacterial action of that compound toward Xac. |
| Databáze: | OpenAIRE |
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