Die Bedeutung von Thrombopoietin (TPO) und seines Rezeptors c-Mpl in der Regulation derThrombozytopoese bei Thrombozytopenien
| Autor: | Gabriele Strauss, Karl Welte, H Schulze, Matthias Ballmaier, Jakob M. Bogenberger, H. Riehm |
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| Rok vydání: | 1996 |
| Předmět: |
endocrine system
medicine.medical_specialty business.industry TAR syndrome food and beverages hemic and immune systems medicine.disease Haematopoiesis Endocrinology medicine.anatomical_structure Megakaryocyte Fanconi anemia hemic and lymphatic diseases Internal medicine embryonic structures Pediatrics Perinatology and Child Health Immunology medicine Platelet Progenitor cell business Thrombopoietin Megakaryocytopoiesis |
| Zdroj: | Klinische Pädiatrie. 208:168-171 |
| ISSN: | 1439-3824 0300-8630 |
| Popis: | Thrombopoietin (TPO) belongs to the family of hematopoietic growth factors. It supports the growth and differentiation of megakaryocytic progenitors and precursors in vitro and in vivo. The predominant site of production of TPO is the liver. However, regulation of TPO serum levels seems to be not due to transcriptional regulation in the liver but due to degradation of circulating TPO by platelets. Thrombopoietin serum levels in children with thrombocytopenia associated with aplastic anemias, Fanconi anemia and TAR syndrome are elevated whereas in children with idiopathic thrombocytopenia the TPO levels are normal. The defective activation of platelets by TPO in a children with TAR syndrome suggests a defective response of megakaryocytopoiesis to TPO. |
| Databáze: | OpenAIRE |
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