Partial Molar Isentropic Compressions of Some Tetra- and Pentapeptides in Aqueous Solution: Implications for Group Additivity Schemes for Unfolded Proteins
| Autor: | Gavin R. Hedwig, Harald Høiland |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Aqueous solution biology Isentropic process Chemistry Biophysics Tripeptide biology.organism_classification Biochemistry Amino acid Crystallography Speed of sound Additive function Simple group Tetra Organic chemistry Physical and Theoretical Chemistry Molecular Biology |
| Zdroj: | Journal of Solution Chemistry. 41:690-701 |
| ISSN: | 1572-8927 0095-9782 |
| Popis: | Sound speeds have been measured for aqueous solutions of five tetrapeptides and five pentapeptides at T=298.15 K. The partial molar isentropic compressions at infinite dilution, \(K_{S,2}^{\circ}\), were derived for the peptides using conventional methods. The results were compared with those calculated using group additivity methods, with the amino acid side-chain contributions derived using \(K_{S,2}^{\circ}\) data reported previously for some tripeptides of sequence gly-X-gly, where X represents an amino acid, and also for some N-acetyl amino acid amides. The tripeptides are the preferred model compounds for the estimation of the side-chain contributions to \(K_{S,2}^{\circ}\) of a polypeptide. Our study also confirms that simple group additivity schemes are not feasible for the estimation of \(K_{S,2}^{\circ}\) values for polypeptides and unfolded proteins. |
| Databáze: | OpenAIRE |
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