422 1.25 DIHYDROXYVITAMIN D(1,25 D) AMELIORATES PREDNISONE INDUCED GROWTH RETARDATION IN LONG EVANS RATS

Autor:	Stephen Osofsky, L. Lyndon Key, Marc Drezner, Patricia M. Baker, Constantine S. Anast
Rok vydání:	1981
Předmět:	Prednisone treatment medicine.medical_specialty Vitamin D metabolism Growth retardation business.industry Weanling D-1 Long evans rats Endocrinology Prednisone Internal medicine Pediatrics Perinatology and Child Health medicine business Linear growth medicine.drug
Zdroj:	Pediatric Research. 15:510-510
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-198104001-00433
Popis:	High-dose prednisone therapy in rapidly growing children is complicated by decreased linear growth. Alterations in Vitamin D metabolism are proposed as a factor contributing to this. To test this hypothesis, 50ng of 1,25 D were administered to weanling Long Evans rats, in addition to 1.0mg of prednisone, from days 21-45. This 21 day period represents the period of most rapid growth for the weaned rats. The mean increments of growth (cm ± SD) for the prednisone treatment and control groups are as follows: The mean increment of growth for rats treated with prednisone is significantly less than the sham-fed group and the group treated with 1,25 D(p 0.2). Thus, 1,25 D supplementation improves growth when administered to rats receiving high-dose prednisone therapy. This supports the hypothesis that decreased 1,25 D contributes to reduced growth during high-dose prednisone therapy. *analysis by single-tailed t test.
Databáze:	OpenAIRE
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