Blood Transfusion and Blood Gas Analysis. Optimal pH Range of Stored Blood

Autor:	Atsushi Uehira
Rok vydání:	1995
Předmět:	Blood transfusion Chemistry medicine.medical_treatment Atp content Blood preservation Oxygen transport Red blood cell medicine.anatomical_structure Biochemistry medicine Ph range Food science Blood gas analysis Whole blood
Zdroj:	Journal of the Japan Society of Blood Transfusion. 41:256-263
ISSN:	1883-8383 0546-1448
DOI:	10.3925/jjtc1958.41.256
Popis:	Changes in ATP content and P50 of the blood during storage play an important role in oxygen transport and red blood cell viability. Three types of stored blood, namely CPD whole blood, CPD-CRC and MAP-CRC, with respect to blood gases, pH and l-lactate concentration ware examined. The number of days of storage correlated with blood acidity and l-lactate concentration, and P50 correlated with pH. On the basis of these observations, the efficacy of high CO2 permeability bags for blood preservation was tested. Blood PCO2 remained lower and pH and P50 higher on storage in these bags than on storage in conventional bags. I also examined the effects of pH change on ATP and 2, 3-DPG levels by addition of l-lactate to the stored blood. When pH of the blood was higher than 6.9, ATP level decreased significantly. When pH range was lower than 6.8, 2, 3-DPG level decreased. These results suggest that pH between 6.8 and 6.9 is optimal for the simultaneous maintenance of adequate ATP and 2, 3-DPG (and thus also P50) levels.
Databáze:	OpenAIRE
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