Biological Versus Chronological Aging
| Autor: | Ana Barettino, Vicente Andrés, Rosa M Nevado, Valentin Fuster, Magda R. Hamczyk |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Gerontology
Population ageing business.industry Vascular disease Biological age Psychological intervention Disease 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences 0302 clinical medicine Health care Medicine 030212 general & internal medicine Risk factor Cardiology and Cardiovascular Medicine business Socioeconomic status |
| Zdroj: | Journal of the American College of Cardiology. 75:919-930 |
| ISSN: | 0735-1097 |
| Popis: | Aging is the main risk factor for vascular disease and ensuing cardiovascular and cerebrovascular events, the leading causes of death worldwide. In a progressively aging population, it is essential to develop early-life biomarkers that efficiently identify individuals who are at high risk of developing accelerated vascular damage, with the ultimate goal of improving primary prevention and reducing the health care and socioeconomic impact of age-related cardiovascular disease. Studies in experimental models and humans have identified 9 highly interconnected hallmark processes driving mammalian aging. However, strategies to extend health span and life span require understanding of interindividual differences in age-dependent functional decline, known as biological aging. This review summarizes the current knowledge on biological age biomarkers, factors influencing biological aging, and antiaging interventions, with a focus on vascular aspects of the aging process and its cardiovascular disease related manifestations. |
| Databáze: | OpenAIRE |
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