Association of Promoter Polymorphism of MMP-1 rs1799750 and MMP-3 rs3025058 with circulating levels of MMP-1 and MMP-3 in patients with Rheumatoid Arthritis

Autor:	Aparna Sagare, Sucheta Dandekar, Anjali Rajadhyaksha
Rok vydání:	2022
Předmět:	Bioengineering Applied Microbiology and Biotechnology Biotechnology
Zdroj:	Research Journal of Biotechnology. 17:111-118
ISSN:	2278-4535 0973-6263
DOI:	10.25303/1703rjbt111118
Popis:	The genetic background of Rheumatoid arthritis (RA) is only partly understood and several genes seem to be involved. Matrix metalloproteinases (MMPs) are involved in joint destruction in rheumatoid arthritis (RA). MMP1 (interstitial collagenase) and MMP3 (stromelysin 1) as most studied enzymes in RA. In the present study, we have investigated the genotypic and haplotypic relationships of the MMP-1 and MMP-3 genes with circulating levels of these MMPs. Functional relevance in single-nucleotide polymorphisms (SNPs)in rs1799750 (1G/2G, MMP-1 promoter) and rs3025058 (5A/6A, MMP-3 promoter) genotyped in 60 RA patients and 60 healthy control is used to determine association of polymorphisms with the severity of the disease. The MMP-3 SNPs were associated with serum MMP-3 level (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2578d69bbc27783c9a53aad262037b3c https://doi.org/10.25303/1703rjbt111118 Zobrazit plný text záznamu