Detection of Antibodies to Human T Cell Lymphotrophic Virus-I/II and Strongyloides Stercoralis Among Pregnant Women on Antenatal Visits to Selected Hospitals in Jos, Nigeria

Autor: Nkup, J. Y, Aminu, M Inabo, H. I, David, S.A, Cirfat, N. A, Katnap, R. S, uhammad, R. I, Adamu, R, Goyil, G.A, Abubakar, F, Aliyu, A.H
Rok vydání: 2022
Předmět:
Zdroj: Saudi Journal of Biomedical Research. 7:57-66
ISSN: 2518-3222
2518-3214
DOI: 10.36348/sjbr.2022.v07i01.008
Popis: Human T cell Lymphotrophic Virus (HTLV-I/II) is an oncogenic retrovirus known to cause adult T cell leukemia which is transmitted vertically from mother to child and sexually by infected lymphocytes. Studies suggest that the onset of adult T-cell leukemia/lymphoma (ATL) in patients infected with HTLV-I/II occurs significantly earlier when the subjects are coinfected with S. stercoralis. This study was aimed at detecting antibodies to HTLV-I/II and Strongyloides stercoralis larvae among pregnant women on antenatal visits to selected hospitals in Jos, Nigeria. A total of 188 blood samples and 136 stool samples were collected for study. Five milliliters (5ml) of venous blood was collected and transferred into a screw capped plastic tube without anticoagulant and sera extracted from each participant’s sample and later analyzed for antibodies to HTLV-I/II using double-antigen sandwich enzyme linked immunosorbent assay (ELISA) kit. Stool samples were also analyzed using direct stool microscopy and Baemanns technique. Questionnaires were administered for participants’ demographics and assessment of risk factors. Data obtained were then analyzed using SPSS version 17. Human T cell Lymphotrophic Virus –I/II prevalence of 2.13% (4/188) was detected following the ELISA procedures with 1.06% (2/188) indeterminate results. Risk factors assessed had no statistical association with HTLV-I/II infection except for history of cancer in a family. Five parasite species were detected on stool examination with 2.2% prevalence of Strongyloides stercoralis. Keeping of pet dogs and having itching around legs were statistically associated with Strongyloidiasis (P< 0.05). Routine monitoring of HTLV-I/II and dewormming of pregnant women on antenatal should be a matter of priority.
Databáze: OpenAIRE
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