Microaggregated Egg Albumin Particles Containing Paraoetamol Tableting Processes
Autor: | J. J. Torrado-Duran, J. J. Torrado-Valeiras, Y. R. Cadorniga |
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Rok vydání: | 1991 |
Předmět: |
Pharmacology
Chromatography biology Chemistry organic chemicals digestive oral and skin physiology Organic Chemistry Egg albumin Pharmaceutical Science Bitter taste Bioavailability Excretion Tableting Ovalbumin health services administration Drug Discovery biology.protein Particle size Flow properties |
Zdroj: | Drug Development and Industrial Pharmacy. 17:1305-1323 |
ISSN: | 1520-5762 0363-9045 |
DOI: | 10.3109/03639049109057299 |
Popis: | Microaggregated egg albumin particles containing paracetamol were prepared by a new microencapsulation method. Thus, paracetamol was suspended into an ovalbumin solution and then heated to coagulate the protein. The paracetamol crystals were entrapped into the new protein structure and as a consequence microaggregated egg albumin particles were obtained. This novel microencapsulation method improved the flow properties of paracetamol powder that are normally poor. The flow characteristics of the microaggregated particles depended on the paracetamol concentration and the particle size. Furthermore, the bitter taste of paracetamol was masked by this microencapsulation method and the microaggregated particles were used to produce chewable and non chewable paracetamol tablets. The “in vivo” oral relative bioavailability of these two kinds of tablets oF microencapsulated paracetamol in six volunteers were 99.5 and 92.5%, respectively, as determined from the urinary accumulative excretion. |
Databáze: | OpenAIRE |
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