Effects of Cigarette Smoking on the Ultrastructure of Rat Thoracic Aorta and Its Ability to Produce Prostacyclin

Autor:	Sj Machin, N Woolf, R M Pittilo, P M Rowles, I. J. Mackie
Rok vydání:	1982
Předmět:	Smoke medicine.medical_specialty Aorta business.industry Prostacyclin Hematology Anatomy In vitro Endocrinology Internal medicine medicine.artery Platelet adhesiveness cardiovascular system Ultrastructure medicine Thoracic aorta Platelet business medicine.drug
Zdroj:	Thrombosis and Haemostasis. 48:173-176
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1657250
Popis:	SummaryFollowing exposure of rats to graded doses of fresh cigarette smoke, the aortic endothelium examined by scanning electron microscopy regularly showed alterations. These essentially consisted of areas of blebbing and microvillus-like projections from the luminal surface, and the presence in the majority of cases, of micro-thrombi in the low shear areas just proximal to intercostal branches. Aortas from rats exposed to smoke showed a reduction in prostacyclin production in vitro and platelets from these animals aggregated more readily than did those of controls.
Databáze:	OpenAIRE
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