Anti-neuroinflammatory asarone derivatives from the rhizomes of Acorus tatarinowii
| Autor: | Xiao-Rui Cheng, Yang Yu, Xin-Sheng Yao, Wei-Yang Zhang, Wen-Xia Zhou, Xiao-Lin Feng, Da-Peng Qin, Hao Gao |
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| Rok vydání: | 2017 |
| Předmět: |
Microglia
010405 organic chemistry Stereochemistry General Chemical Engineering General Chemistry 01 natural sciences Acorus tatarinowii 0104 chemical sciences Rhizome 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry Cell culture Toxicity medicine Asarone Tumor necrosis factor alpha Enantiomer 030217 neurology & neurosurgery |
| Zdroj: | RSC Advances. 7:8512-8520 |
| ISSN: | 2046-2069 |
| Popis: | A novel 7-O-7′ type mesomeric neolignan, meso-asarolignan A (1), six pairs of new neolignan enantiomers, (±)-asarolignan B–G (2a/2b, 3a/3b, 4–6, 7a/7b), along with 16 known analogues (8–23) were isolated from the rhizomes of Acorus tatarinowii. The structures of the new compounds were elucidated by extensive analysis of spectroscopic, X-ray diffraction, and computational data. Compounds 1–3 represent rare examples of naturally occurring lignans with a 7-O-7′ linkage pattern. All isolated compounds were assayed for their anti-neuroinflammatory effects on tumor necrosis factor α (TNF-α) production in an activated murine microglia cell line. Compounds 7(a/b), 14(a/b), 16, 20, and 22 reduced TNF-α levels without high cell toxicity in LPS-activated BV-2 cells. |
| Databáze: | OpenAIRE |
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