| Popis: |
Rituximab is a chimeric anti-CD20 monoclonal antibody (mAb) and the first mAb to be approved for use in the treatment of cancer. The proposed mechanisms of action of rituximab include antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and induction of apoptosis. The influences of CD20 expression level, circulating soluble CD20, Fcγ receptor (FcγR) polymorphisms, complement regulatory proteins, and C1qA-276 polymorphisms on susceptibility and resistance to rituximab have been previously described. In a pharmacokinetic study, from the first to the fourth or eighth weekly dose of rituximab, post-infusion serum concentrations increased and steady-state serum concentrations were not reached. The combined use of rituximab and fludarabine, bendamustine, lenalidomide, or histone deacetylase inhibitors may be one of the optimal solutions for overcoming rituximab resistance in the treatment of chronic lymphocytic leukemia (CLL). The characteristic toxicities of rituximab are infusion reactions, late-onset neutropenia, hepatitis B virus reactivation, and opportunistic infections. |
