| Autor: | Naoyuki Nishizawa, Takashi Nagasawa, David D. Kitts, Nobuaki Tabata, Yoshiaki Ito, Youichi Aiba |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Kidney Clinical chemistry Chemistry Clinical Biochemistry Cell Biology General Medicine Streptozotocin medicine.disease Blood proteins Rutin chemistry.chemical_compound Endocrinology medicine.anatomical_structure Glycation Internal medicine Diabetes mellitus medicine Biomarker (medicine) Molecular Biology medicine.drug |
| Zdroj: | Molecular and Cellular Biochemistry. 252:141-147 |
| ISSN: | 0300-8177 |
| DOI: | 10.1023/a:1025563519088 |
| Popis: | The present study focused on examining the efficacy of feeding a rutin-glucose derivative (G-rutin) to inhibit glycation reactions that can occur in muscle, kidney and plasma proteins of diabetic rats. Both thiobarbituric acid-reactive substance levels and protein carbonyl contents in muscle and kidney were significantly (p < 0.05) reduced in streptozotocin-induced diabetic rats fed G-rutin supplemented diet, compared to diabetic rats fed control diet. The Ne-fructoselysine content in muscle and kidney, a biomarker of early glycation reaction, was markedly (p < 0.05) increased by diabetes, but significantly (p < 0.05) reduced in diabetic rats fed G-rutin. Advanced glycation end-products (AGEs) in serum and kidney protein were measured by immunoblot using anti-AGE antibody, and were also reduced in diabetic rats fed dietary G-rutin. Feeding G-rutin also slightly inhibited aldose reductase activity in these animals. These results demonstrate for the first time that dietary G-rutin consumption can provide potential health benefits that are related to the inhibition of tissue glycation reactions common to diabetes. |
| Databáze: | OpenAIRE |
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