A new model for measuring concentration of antibiotics in prostatic interstitial fluid
| Autor: | N. G. Waterman, L. Scharfenberger, H. U. Eickenberg |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Microbiology (medical)
Pathology medicine.medical_specialty medicine.drug_class business.industry Antibiotics Soft tissue Prostatitis General Medicine medicine.disease Infectious Diseases medicine.anatomical_structure Pharmacokinetics Prostate Interstitial fluid medicine business Subcutaneous tissue |
| Zdroj: | Infection. 4:S108-S112 |
| ISSN: | 1439-0973 0300-8126 |
| DOI: | 10.1007/bf01674479 |
| Popis: | Utilizing multiperforated capsules implanted into subcutaneous tissue and the prostate in dogs, the concentration of cephalothin in soft tissue interstitial fluid (STIF) and prostatic interstitial fluid (PIF) was measured simultaneously and compared with concentration in serum. At all times the antibiotic concentration in PIF was lower than levels found in STIF and serum. This model may aid in the understanding of the basic pharmocokinetics of antibiotics in the prostatic interstitium and provide guidelines for treatment of prostatitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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