Extracellular RNAs and Extracellular Vesicles: Inception, Current Explorations, and Future Applications
| Autor: | Saptashwa Datta, Selvarajan Ethiraj, Jayachandran Krishna, Melvin S. Samue, Chae Rin Park, Ayyappasamy Sudalaiyadum Perumal, Ramachandran Chelliah |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Journal of Food Hygiene and Safety. 35:535-543 |
| ISSN: | 2465-9223 1229-1153 |
| DOI: | 10.13103/jfhs.2020.35.6.535 |
| Popis: | In addition to the ubiquitous roles of cellular RNA in genetic regulations, gene expression and phenotypic variations in response to environmental cues and chemotactic signals, the regulatory roles of a new type of RNA called extracellular RNAs (exRNAs) are an up-and-coming area of research interest. exRNA is transported outside the cell through membrane blebs known as membrane vesicles or extracellular vesicles (EVs). EV formation is predominant and conserved among all microbial forms, including prokaryotes, eukaryotes, and archaea. This review will focus on the three major topics concerning bacterially derived exRNAs, i.e., 1) the discovery of exRNA and influence of extraneous RNA over bacterial gene regulations, 2) the known secretion mechanism for the release of exRNA, and 3) the possible applications that can be devised with these exRNA secreted by different gram-negative and gram-positive bacteria. Further, this review will also provide an opinion on exRNA- and EV-derived applications such as the species-specific exRNA markers for diagnostics and the possible roles of exRNA in probiotics and the epigenetic regulations of the gut microbiome. |
| Databáze: | OpenAIRE |
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