Mechanistic Elucidation of Hard Agglomerate Formation from Drying Kinetics in the Integrated Sorption Chamber

Autor:	Mark Lindrud, Joshua Engstrom, Deniz Erdemir, Steven H. Chan, Ming Huang, Daniel S. Hsieh
Rok vydání:	2018
Předmět:	Active ingredient Materials science Batch distillation Diffusion Organic Chemistry Kinetics Sorption chemistry.chemical_compound Chemical engineering chemistry Agglomerate Particle-size distribution Acetone Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 22:608-617
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.8b00052
Popis:	The formation of hard agglomerates during drying has impacts on the product quality, particle size distribution, and downstream formulation. Hence, understanding the cause of hard agglomerates and determining a remedy for them or preventing their formation are necessary. The integrated sorption chamber (ISC) has been successfully applied to the study of hard agglomerate formation. The design and development of this ISC are briefly described. The vapor-phase profile of a binary mixture of acetone and water without active pharmaceutical ingredient (API) was predicted using an analytical solution of a batch distillation and verified via mass spectrometry (MS). The drying of the API wet cake, which is very soluble in water, using a starting point of 5 wt % water in acetone was conducted in the ISC. A significant delay in water removal was observed from both the weight measurement and the MS signal. The slow removal of water was attributed to diffusion of water from a thin crust layer induced by the solution o...
Databáze:	OpenAIRE
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