OC-099 Increased at risk screening and recognition of atypical presentation does not fully explain the 6.5-fold increase in paediatric coeliac disease (CD) incidence in the last 20 years in SE Scotland
| Autor: | Peter M. Gillett, Victoria Merrick, David C. Wilson, Lois White, Elaine Bannerman, Richard K Russell, D. Basude, Paul Henderson |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Gut. 61:A43.2-A43 |
| ISSN: | 1468-3288 0017-5749 |
| DOI: | 10.1136/gutjnl-2012-302514a.99 |
| Popis: | Introduction Current diagnostic practice for paediatric CD in the UK includes increased screening of family members and at- risk groups for example, diabetes mellitus. Aims To identify all incident cases of CD in SE Scotland over the 20-year period of 1990–2009 to assess trends in incidence, symptomatology, age at diagnosis and the impact of active screening of at-risk groups. Utility of routine laboratory tests at diagnosis was also evaluated (2005–2009 diagnoses only). Methods A retrospective review of case notes, pathology databases, endoscopy and patient records was performed for all children diagnosed with CD Results 266 biopsy positive children were diagnosed from 1990 to 2009 with an increase in incidence from 1.8 (95% CI 1.1 to 2.7) to 11.7 (95% CI 9.8 to 13.9) per 100 000 children aged Conclusion The incidence of paediatric CD has increased 6.5-fold over the last 20 years in SE Scotland. Children are older at diagnosis, presenting with fewer classical and more varied symptoms, and with iron deficiency anaemia the commonest laboratory abnormality. We show that both increased screening of at-risk groups and a lower threshold for serological screening (as a result of greater clinician awareness of the condition9s heterogeneic nature) do not fully explain the overall rise in incidence. Competing interests None declared. |
| Databáze: | OpenAIRE |
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