1.116 TRACE METALS IN PATIENTS WITH PARKINSON'S DISEASE: A MULTI-CENTER CASE-CONTROL STUDY IN NIGERIAN PATIENTS
| Autor: | O.A. Ogunrin, Morenikeji A. Komolafe, C.C. Osubor, E.O. Sanya |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Pathology Parkinson's disease business.industry Magnesium Case-control study chemistry.chemical_element Zinc Manganese medicine.disease Gastroenterology Pathogenesis Neurology chemistry Internal medicine Toxicity medicine Etiology Neurology (clinical) Geriatrics and Gerontology business |
| Zdroj: | Parkinsonism & Related Disorders. 18:S39 |
| ISSN: | 1353-8020 |
| DOI: | 10.1016/s1353-8020(11)70230-9 |
| Popis: | Background: The roles of environmental factors in the etiologic consideration of Parkinson's disease (PD) need investigation and clarification, especially in sub-Saharan Africa where genetic mutations are rare. Trace metals toxicity has been associated with pathogenesis of neuro-degeneration including Parkinson's disease. Methods: PD patients presenting to three tertiary health facilities located in the south-west, south-south and central Nigeria were studied and compared with age and sex matched controls from the same regions using a protocol containing a structured questionnaire, diagnostic criteria based on the United Kingdom Parkinson's Disease Society brain bank and atomic absorption spectrophotometry method for analysis of plasma trace metals - copper, zinc, magnesium, manganese and iron. Findings: Sixty eight consecutive PD patients with a mean age of 65.7±7.29 years and a male preponderance (Male (46)/Female (22) = 2.1:1) had significantly elevated trace metals (namely copper, zinc, magnesium and iron) compared to controls (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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