Syntheses of AZ12320927 labeled with H-3, C-14, and H-2

Autor:	Mark E. Powell, Charles S. Elmore, J. Richard Heys
Rok vydání:	2008
Předmět:	Stable isotope ratio Chemistry Organic Chemistry Biochemistry Chemical synthesis Analytical Chemistry Catalysis Isotopes of carbon Nucleophilic aromatic substitution Drug Discovery Nucleophilic substitution Organic chemistry Radiology Nuclear Medicine and imaging Carbon-14 Tritium Spectroscopy
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 51:343-346
ISSN:	1099-1344 0362-4803 1232-0927
Popis:	In support of a program to develop a treatment for depression, three isotopically labeled forms of the 5-HT1B antagonist AZ12320927 were synthesized. A tritium labeled version was synthesized for autoradiography using Ir-catalyzed hydrogen–tritium exchange. A C-14 labeled version was prepared for use in metabolism studies in four-steps from [u-14C]p-nitrophenol. A stable isotope labeled version was synthesized for use as an internal standard for LC/MS/MS quantitation in two steps from chromenone 1. Copyright © 2008 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2554d36133b5f0122df28a9a5881f6a3 https://doi.org/10.1002/jlcr.1534 Zobrazit plný text záznamu Plný text