Lipase catalyzed résolutions of some α,α-disubstituted 1,2-diols in organic solvents; near absolute regio and chiral recognition
| Autor: | Richard M. Kellogg, Robert P. Hof |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
biology
organic chemicals fungi Organic Chemistry Substituent Triacylglycerol lipase food and beverages Regioselectivity macromolecular substances Catalysis Stereocenter Inorganic Chemistry chemistry.chemical_compound chemistry biology.protein Vinyl acetate Organic chemistry Physical and Theoretical Chemistry Enantiomer Lipase Aliphatic compound |
| Zdroj: | Tetrahedron: Asymmetry. 5:565-568 |
| ISSN: | 0957-4166 |
| DOI: | 10.1016/0957-4166(94)80019-7 |
| Popis: | Several racemic 1,2-diols bearing a tertiary benzylic alcohol stereogenic center can be esterified regioselectively by vinyl acetate using lipases and esterases in organic media. With the correct choice of enzyme and if the non-phenyl substituent at the tertiary center is unsaturated, E values of > 250 can be achieved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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