Anti-ErbB4 targeting approaches for prostate cancer treatment
| Autor: | Akiva Vexler, Alexander Shtabsky, Loew, Karaush, Ghalib Lidawi, Rami Ben-Yosef, Shahar Lev-Ari, Itay Barnea |
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| Rok vydání: | 2008 |
| Předmět: |
Pharmacology
Cancer Research biology business.industry medicine.drug_class medicine.medical_treatment Monoclonal antibody medicine.disease Targeted therapy Radiation therapy Prostate cancer Oncology Cell culture In vivo Immunology Cancer research biology.protein Molecular Medicine Combined Modality Therapy Medicine Antibody business |
| Zdroj: | Cancer Biology & Therapy. 7:1090-1094 |
| ISSN: | 1555-8576 1538-4047 |
| Popis: | Purpose: To evaluate the efficiency of anti ErbB4 targeted therapy combined with irradiation (XRT) over each modality alone in prostate cancer. Methods: Clones with low and high expression of ErbB4 isolated by a limited dilution technique from an androgen independent Cl-1 cell line were used. The cells from these clones were exposed to XRT (single dose of 2-6 Gy) and to anti-ErbB4 monoclonal antibody (mAb). The XTT test was used to measure cell survival. In addition, tumor bearing nude mice were treated either by XRT, mAb or by a combined treatment. Tumor sizes were recorded at given time points. Results: Clones with high ErbB4 expression grew faster than those with low ErbB4 expression. XRT inhibited the growth of both expressive and non-expressive ErbB4 cells, while mAb inhibited only high ErbB4 expressing cells. The combination of XRT and mAb resulted in a 30% reduction of the survival of high ErbB4 expressing cells over XRT alone (p=0.013). In tumor bearing mice the tumor size in the combined arm was ... |
| Databáze: | OpenAIRE |
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