Influence of Alcohols on Micellar and Release Balances of Cationic Surfactant – Carbethopendecinium Bromide (Septonex)
| Autor: | Petra Herdová, Vitková Z, Jarmila Oremusová |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Tenside Surfactants Detergents. 51:339-347 |
| ISSN: | 2195-8564 0932-3414 |
| DOI: | 10.3139/113.110316 |
| Popis: | An objective of this work is analysis of influence of selected alcohols from the group of enhancers (ethanol, propan-1-ol, propan-2-ol) and humectants (ethane-1,2-diol, propane-1,2-diol and propane-1,2,3-triol) in the hydrogels containing carbethopendecinium bromide on their associative (critical micelle concentration and thermodynamic parameters) and release properties (pH, percentage of drug release and the release rate constant). The studied hydrogels contained constant amounts of the gel-creating basis (polymer chitosan – 2.5% w/w), drug carbethopendecinium bromide (Septonex) – 1.0% w/w and additive of alcohol in 5 and 10% w/w concentrations. Associative parameter – critical micelle concentration (CMC) was evaluated by conductometric measurements. The CMC significantly increased in the environment of alcohols in comparison with water solutions as many as 50 times, while concentration of alcohols ranged within W = 0–100% mass fractions. Micellization in the both environments was spontaneous (ΔGm < 0), and from the energetic point of view it was exothermic (ΔHm < 0). The additive of alcohols in hydrogels supported the drug relase from hydrogels. As the concentration of alcohols increased the mass percentage of the drug released from gel increased as well. |
| Databáze: | OpenAIRE |
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