The essential oil of MongolianNepeta sibirica: a single component and its biological activities

Autor:	Kazuo Koike, Fumio Kato, Altantsetseg Shataryn, Amarjargal Ayurzana, Shatar Sanduin, Wei Li, Tsutomu Tsuruoka, Tadaaki Satou, Davaapurev Bekh-Ochir
Rok vydání:	2012
Předmět:	biology Traditional medicine General Chemistry biology.organism_classification medicine.disease_cause Antimicrobial Aspergillus fumigatus law.invention chemistry.chemical_compound Nepetalactone chemistry law Staphylococcus aureus Botany medicine Gas chromatography–mass spectrometry Candida albicans Escherichia coli Essential oil
Zdroj:	Journal of Essential Oil Research. 24:555-559
ISSN:	2163-8152 1041-2905
DOI:	10.1080/10412905.2012.729925
Popis:	Nepeta sibirica L. has been used for the treatment of various diseases and is one of the traditional medicines of Mongolia. The essential oil of N. sibirica was shown to contain a single component by gas chromatography–mass spectrometry (GC–MS) analysis. The optical rotation and nuclear magnetic resonance (NMR) analyses demonstrated that the component was 4aα,7α,7aα-nepetalactone. This essential oil, that is, 4aα,7α,7aα-nepetalactone, showed antimicrobial activity against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus fumigatus. Cell cytotoxicity testing showed that the nepetalactone was cytotoxic to HL60 myeloma and Kato III stomach carcinoma cell lines. The essential oil of this Mongolian N. sibirica is useful for researching the bioactivity of nepetalactone, which has been difficult to prepare.
Databáze:	OpenAIRE
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