CONVALESCENT PLASMA: ITS EFFECTIVENESS IN TREATING MODERATE AND SEVERE CASES OF COVID 19 IN A TERTIARY CARE CENTRE IN UTTARAKHAND

Autor: Neha Batra, Sana Umar, Nidhi Uniyal, Arvind Kumar, Deepa Hatwal, Sushil Ojha, Snigdha Petwal
Rok vydání: 2022
Zdroj: INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH. :12-14
Popis: Introduction: Convalescent plasma, is the component of blood which contains antibodies and is obtained from people that have recovered from COVID- 19.These antibodies have antiviral properties and may be useful inCOVID 19 patientsIn ourstudy we intend to study the benets of plasma by observing various clinical parameters on patients before and after therapy. If a signicant improvement is seen we can suggest its use in the treatment of COVID-19. Since the current pandemic has taken a toll on millions of lives so far, it is important that we come up with newer treatment methods and also study the importance and relevance of already suggested treatment modalities to improve patient care. Aim : To study the effectiveness ofCOVID- 19 convalescent plasma in the treatment ofCOVID-19 by comparing 28 daymortality and variouslab parameters and clinical improvement of patients that received plasma therapy vs those that did not. Material Method: This is a clinical case control study from September 2020 to May 2021 conducted in Blood Bank, Government Doon Medical College and Hospital, Dehradun. 100 patients suffering with moderate and severeCOVID 19 disease were taken in the study who were transfused with convalescent plasma and 100 control patients were taken who were only given bestsupportive treatment.Various clinical and serological parameterswere studied in the two groups to see its effectiveness on the patientsstatus. Serological parameters included in the study are C- reactive protein, IL-6 and serum Ferritin. Results: On performing chi square test, no signicant difference between plasma and control groupsin the clinical outcome after 28 days both formoderate cases(P=0.261) and severe cases(P=0.191) was found. The overall difference in mortality in the two groups was also not statistically signicant (p=0.415). The mean biochemical lab parameters showed an overall downward trend in both the groups but difference in the improvement was notstatistically signicant except in case of interleukin 6 that improved signicantly in patients that received plasma therapy (p=0.01) Summary: Convalescent Plasma therapy did not show any additional benetinclinicaloutcome,reductionin28daymortality andlabparameterss exceptforIL-6.
Databáze: OpenAIRE
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