Monomicrobial Fournier's Gangrene Caused by Panton-Valentine Leukocidin-negative Methicillin-susceptible Staphylococcus aureus ST8 in Japan
| Autor: | Nozomi Murooka, Kenichi Kawahori, Noriaki Ohkiba, Hirofumi Yamagishi, Takeshi Inazawa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Gangrene
business.industry SCCmec Leukocidin Virulence Toxic shock syndrome General Medicine biochemical phenomena metabolism and nutrition 030204 cardiovascular system & hematology bacterial infections and mycoses medicine.disease_cause medicine.disease Microbiology 03 medical and health sciences 0302 clinical medicine Staphylococcus aureus Internal Medicine Medicine 030211 gastroenterology & hepatology Panton–Valentine leukocidin skin and connective tissue diseases business Methicillin Susceptible Staphylococcus Aureus |
| Zdroj: | Internal Medicine. 59:1769-1772 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.4334-19 |
| Popis: | Methicillin-resistant Staphylococcus aureus USA300, belonging to sequence type (ST) 8, is a rare cause of necrotizing fasciitis in the USA. We herein report a case of monomicrobial Fournier's gangrene caused by an ST8, methicillin-susceptible Staphylococcus aureus (designated ksw1). Whole-genome sequencing and analyses for virulence determinants revealed that, unlike USA300, ksw1 lacked virulence genes, such as Panton-Valentine leukocidin and SCCmec, while harboring the toxic shock syndrome toxin-1 gene. These genomic features correlate with ST8 CA-MRSA/J, which is the major genotype of ST8 in Japan. |
| Databáze: | OpenAIRE |
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