PROGNOSTIC FACTORS OF RENAL TUMOR RECURRENCE AFTER RADICAL NEPHRECTOMY

Autor:	P Ibero Casadiego, J L Rodicio Miravalles, A R Arnaiz Pérez, R Molina Escudero, B Carrasco Aguilera, M Merayo Álvarez, E Escolano Fernández, G Martínez Izquierdo
Rok vydání:	2021
Předmět:	medicine.medical_specialty Univariate analysis business.industry medicine.medical_treatment Urology Cancer medicine.disease Comorbidity Preoperative care Nephrectomy medicine.anatomical_structure Renal cell carcinoma Adjuvant therapy medicine Surgery business Renal sinus
Zdroj:	British Journal of Surgery. 108
ISSN:	1365-2168 0007-1323
Popis:	INTRODUCTION Renal cell carcinoma (RCC) represents 3% of overall malignant neoplasms in adults. However, its aetiology has not been clearly established. Although surgery represents the cornerstone in treatment, recurrence postoperative rates are around 20-30%, what implies prognostic factors search must be mandatory in order to help to plan de follow-up and the different adjuvant therapy possibilities available in case they were necessary. MATERIAL AND METHODS A retrospective observational study was carried out in 110 patients who underwent radical nephrectomy between 2004 and 2018, with the aim of identifying possible prognostic factors of recurrence of RCC after these surgeries. Preoperative data (epidemiological, comorbidities and laboratory tests), surgical, pathological and variables related to follow-up were taken into account. A univariate and multivariate analysis were performed, using chi-square test and logistic regression, respectively. RESULTS The median follow-up time was 53.5 months (SD = 35.8), time in which 19 patients had a recurrence of RCC after radical nephrectomy (17.2%). Histopathological items such as the surgical piece size, the nodal and microvascular invasion, the renal sinus invasion and the presence of necrosis in the surgical piece were associated with RCC recurrence in the univariate analysis, while only the presence of necrosis in the surgical piece showed a significant result in the multivariate analysis (p = 0.004). CONCLUSIONS Histopathological analysis, highlighting the presence of necrosis in the histological sample, was proved to be the main risk factor of RCC recurrence.
Databáze:	OpenAIRE
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