Feature Article: Polymeric Nanoparticulate Drug Delivery Through The Blood Brain Barrier
| Autor: | Tejraj M. Aminabhavi, N. N. Mallikarjuna, Frederick J. Bonte, Celeste A. Roney, Sanjeev K. Manohar, M. Sairam, Aimei Wu, Veera Arora, Peter P. Antich, Michael J. Bennett, Padmakar V. Kulkarni |
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| Rok vydání: | 2005 |
| Předmět: |
Polymers and Plastics
biology business.industry Clioquinol Central nervous system Tau protein Pharmacology Blood–brain barrier medicine.anatomical_structure Targeted drug delivery Nanoparticles for drug delivery to the brain Drug delivery medicine biology.protein Chemical Engineering (miscellaneous) Senile plaques business medicine.drug |
| Zdroj: | Polymer News. 30:311-321 |
| ISSN: | 0032-3918 |
| DOI: | 10.1080/00323910500290374 |
| Popis: | Alzheimer's disease (AD) is the most common cause of dementia among the elderly, affecting 5% of Americans over age 65, and 20% over age 80. An excess of senile plaques (β-amyloid protein) and neurofibrillary tangles (tau protein), ventricular enlargement, and cortical atrophy characterizes it. Unfortunately, targeted drug delivery to the Central Nervous System (CNS), for the therapeutic advancement of neurodegenerative disorders such as Alzheimer's, is complicated by restrictive mechanisms imposed at the blood brain barrier (BBB). Opsonization by plasma proteins in the systemic circulation is an additional impediment to cerebral drug delivery. Here, we attempt to show that biodegradable polymeric nanoparticles (NPs) with appropriate surface modifications can deliver drugs of interest beyond the BBB for diagnostic and therapeutic applications, thus allowing the study of neurological disorders. Particularly, the radiolabelled Cu2+ or Fe3+ metal chelator Clioquinol (CQ), which has a high affinity f... |
| Databáze: | OpenAIRE |
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