Melatonin and colon carcinogenesis
| Autor: | V Berman, Pavel Gurevich, Shtylik Av, M. A. Zabezhinski, V. N. Anisimov, H. Ben-Huh, Irina G. Popovich, Y Tendler, I Zusman |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
endocrine system
medicine.medical_specialty business.industry Cell Biology General Medicine Toxicology medicine.disease_cause medicine.disease Pathology and Forensic Medicine Descending colon 1 2-Dimethylhydrazine Melatonin chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Apoptosis Internal medicine medicine Carcinoma Carcinogenesis business Anticarcinogen Carcinogen medicine.drug |
| Zdroj: | Experimental and Toxicologic Pathology. 52:71-76 |
| ISSN: | 0940-2993 |
| DOI: | 10.1016/s0940-2993(00)80022-6 |
| Popis: | Summary Forty-eight two-month-old outbred female LIO rats were injected weekly with a single dose of 1,2-dimethylhydrazine (DMH; 21 mg/kg of body weight) administered s.c. for 15 consecutive weeks. From the day of the 1st injection of the carcinogen the part of rats were given five days a week during the night time (from 18.00 h to 08.00 h) melatonin dissolved in tap water, 20 mg/l. 10 rats were treated similaly with solvents and served as control. The experiment was terminated 6 months after the first injection of the carcinogen. Colon tumors (mainly adenocarcinomas) developed in a hundred percent of rats exposed both to DMH or to DMH plus melatonin. However, descending colon carcinomas were observed in 65% of rats exposed to DMH plus melatonin against 100% in those exposed to DMH alone (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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